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GRK 2624
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Research
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Projects
P5: ExpTimeDose-DoE
parameters of interest, such as the maximum tolerated dose, can be estimated precisely (Dette et al., 2010, among many others). There are several approaches to determine optimal designs for time dependent [...] used for the models developed in project P2 and P3. References Dette H, Kiss C, Bevanda M, Bretz F (2010). Optimal designs for emax, log-linear and exponential models. Biometrika 97 (2), 513-518, doi: 10 …